Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Viral vectors

Tools for in vivo and in vitro modulation of gene expression

We use and/or build virals vectors in order to over- or -underexpress genes of interest in vitro and in vivo :

• lentiviral vectors (LV)

• adeno-associated vectors (AAV)

• adenoviral vectors (Ad) 

Exemples :

In vitro

In vivo

BHLHE40 transcription factor overexpression in muscle cells induced myotube atrophy.                                                                                                                                    

Lecomte et al. Mol Cel Biol 2010

Mouse muscle overexpression of GFP/ SREBP-1 transcription factor. Muscle histology revealed fiber size reduction.                                                                                                           

Lecomte et al. Mol Cel Biol 2010

Injection of LV-AARE-LUC in mouse pancreas. Luciferase expression is under the control of an artificial promoter based on AARE sequences and –Ile is the inducer (see NUTRIREG).

Chaveroux et al, Nature Biotech. 2016

General informations :

As well as viruses, viral vectors are able to enter into and to genetically modify targed cells. Cellular and tissular specificity depend on serotype. Besides, genetic modification could be stable or transient, according to kind of viral vector.

Viral vectors could (1) express a transgene of interest, or (2) express a shRNA in order to shut down transgene of interest expression. Unlike viruses, viral vectors are devoid of their replication ability.

Contact : 

Cyrielle VITURET