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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Our Publications


- Specific shifts in the endocannabinoid system in hibernating brown bears. Boyer C, Cussonneau L, Brun C, Deval C, Pais de Barros JP, Chanon S, Bernoud-Hubac N, Daira P, Evans AL, Arnemo JM, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Combaret L, Bertile F, Lefai E. Front Zool. 2020 Nov 23;17(1):35. doi: 10.1186/s12983-020-00380-y.

- Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization. Deval C, Calonne J, Coudy-Gandilhon C, Vazeille E, Bechet D, Polge C, Taillandier D, Attaix DCombaret L. Int J Mol Sci. 2020 May 23;21(10):3691. doi: 10.3390/ijms21103691.


- Magnesium transport and homeostasis-related gene expression in skeletal muscle of young and old adults: analysis of the transcriptomic data from the PROOF cohort Study. Coudy-Gandilhon C, Gueugneau M, Taillandier DCombaret L, Polge C, Roche F, Barthélémy JC, Féasson L, Maier JA, Mazur A, Béchet D. Magnes Res. 2019 Aug 1;32(3):72-82. doi: 10.1684/mrh.2019.0458.

- Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model. Groussard C, Maillard F, Vazeille E, Barnich N, Sirvent P, Otero YF, Combaret L, Madeuf E, Sourdrille A, Delcros G, Etienne M, Teixeira A, Sauvanet P, Pialoux V, Boisseau N. Oxid Med Cell Longev. 2019 Jul 14;2019:1965364. doi: 10.1155/2019/1965364.

- Chalvon-Demersay T, Moro J, Even PC, Chaumontet C, Tomé D, Averous J, Piedcoq J, Gaudichon C, Maurin AC, Fafournoux P, Azzout-Marniche D. Liver GCN2 controls hepatic FGF21 secretion and modulates whole-body postprandial oxidation profile under a low-protein diet.2019Am J Physiol Endocrinol Metab. Oct 1. doi: 10.1152/ajpendo.00022.2019. [Epub ahead of print]

- Aniort J, Stella A, Philipponnet C, Poyet A, Polge C, Claustre A, Combaret L, Béchet D, Attaix D, Boisgard S, Filaire M, Rosset E, Burlet-Schiltz O, Heng AE, Taillandier D. Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work. 2019 Journal of Cachexia, Sarcopenia and Muscle.

- Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin A-C, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB and O'Rahilly S. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.2019 Cell Metabolism.

- Maillard F, Vazeille E, Sauvanet P, Sirvent P, Combaret L, Sourdrille A, Chavanelle V, Bonnet R, Otero YF, Delcros G, Barnich N, Boisseau N. High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota. 2019 PLoS One.

- Tascher G, Burban A, Camus S, Plumel M, Chanon S, Le Guevel R, Shevchenko V, Van Dorsselaer A, Lefai E, Guguen-Guillouzo C, Bertile F. In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes.2019 Cells.

- Le Bacquer O, Combe K, Patrac V, Ingram B, Combaret L, Dardevet D, Montaurier C, Salles J, Giraudet C, Guillet C, Sonenberg N, Boirie Y, Walrand S. 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.2019 Journal of Cachexia, Sarcopenia and Muscle.

- Maillard F, Vazeille E, Sauvanet P, Sirvent P, Bonnet R, Combaret L, Chausse P, Chevarin C, Otero Y, Delcros G, Chavanelle V, Boisseau N and Barnich N. Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn’s Disease Susceptibility. 2019 Cells.8(1):33. 

- Mohamed AB, Remond D, Chambon C, Sayd T, Hébraud M, Capel F, Cohade B, Hafnaoui N, Béchet D, Coudy-Gandilhon C, Migne C, David J, Dardevet D, Dore J, Polakof S and Savary-Auzeloux I. A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs. 2019 Journal of Nutritional Biochemistry.65:72-82.


- Polge C, Cabantous S, Deval C, Claustre A, Hauvette A, Bouchenot C, Aniort J, Béchet D, Combaret L, Attaix D and Taillandier D. A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate.2018 Journal of Cachexia, Sarcopenia and Muscle. 9(1):129-145.

- Bernardo K, Jousse C, Fafournoux P, Schiphorst AM, Grand M, Robins RJ, Hankard R and De Luca A. Protein restricted diet during gestation and/or lactation in mice affects 15N natural isotopic abundance of organs in the offspring: Effect of diet 15N content and growth.2018 Plos One.13(10).

- Delbrel E, Soumare A, Naguez A, Label R, Bernard O, Bruhat A, Fafournoux P, Tremblais G, Marchant D, Gille T, Bernaudin JF, Callard P, Kambouchner M, Martinod E, Valeyre D, Uzunhan Y, Planès C and Boncoeur E. HIF-1alpha triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis.2018 Scientific Reports.8(1)

- Gatineau E, Cluzet S, Krisa S, Papet I, Migné C, Rémond D, Dardevet D, Polakof S, Richard T and Mosoni L. Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients.2018 Food and Function. 9(5):2922-2930.

- Gueugneau M, d'Hose D, Barbé C, de Barsy M, Lause P, Maiter D, Bindels LB, Delzenne NM, Schaeffer L, Gangloff Y-G, Chambon C, Coudy-Gandilhon C, Béchet D and Thissen J-P. Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy. 2018 Journal of Cachexia, Sarcopenia and Muscle. 

- Martin O, Naud N, Tache S, Debrauwer L, Chevolleau-Mege S, Dupuy J, Chantelauze C, Durand D, Pujos-Guillot E, Blas-Y-Estrada F, Urbano C, Kuhnle GG, Sante-Lhoutellier V, Sayd T, Viala D, Blot A, Meunier N, Schlich P, Attaix D, Gueraud F, Scislowski V, Corpet D and Pierre F. Targeting colon luminal lipid peroxidation limits colon carcinogenesis associated with red meat consumption. 2018 Cancer Prevention Research. 11(9):569-580.

- Pickering G, Macian N, Papet I, Dualé C, Coudert C and Pereira B. N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects. 2018 Fundamental and Clinical Pharmacology.

- Polge C, Aniort J, Armani A, Claustre A, Coudy-Gandilhon C, Tournebize C, Deval C, Combaret L, Béchet D, Sandri M, Attaix D and Taillandier D. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment.2018 Cells.7(11) 

- O’keeffe M, Kelly M, O’herlihy E, O’toole PW, Kearney PM, Timmons S, O’Shea E, Stanton C, Hickson M, Rolland Y, Sulmont-Rossé C, Issanchou S, Maitre I, Stelmach-Mardas M, Nagel G, Flechtner-Mors M, Wolters M, Hebestreit A, De Groot L, van de Rest O, Teh R, Peyron M-A, Dardevet D, Papet I, Schindler K, Streicher M, Torbahn G, Kiesswetter E, Visser M, Volkert D, O’connor EM and consortium obotM. Potentially modifiable determinants of malnutrition in older adults: a systematic review.2018 Clinical Nutrition. in press:1-64.

- Mast C, Dardevet D and Papet I.Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case.2018 Nutrition Research Reviews.31(2):179-192.


- Mast C, Pourpe C, Voyard G, Rémond D, Migné C, Centeno D, Dardevet D, Savary-Auzeloux I and Papet I. Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats. 2017 British Journal of Nutrition. 118(11):889-896. 

- Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier S and Sirvent P. Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice.2017 Scientific Reports.7(1):10 p.

- Louessard M, Bardou I, Lemarchand E, Thiebaut AM, Parcq J, Leprince J, Terrisse A, Carraro V, Fafournoux P, Bruhat A, Orset C, Vivien D, Ali C, Roussel BD. Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death. 2017 Cell Death Differ. Sep;24(9):1518-1529.

- Mesclon F, Lambert-Langlais S, Carraro V, Parry L, Hainault I, Jousse C, Maurin AC, Bruhat A, Fafournoux P, Averous J. Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells. 2017 Oncotarget Apr 18;8(16):27440-27453.

- Bruhat A, Fafournoux P. The CCAAT/enhancer-binding protein-ATF response elements-luciferase mouse model, an innovative tool to monitor the integrated stress response pathway in vivo. 2017 Curr Opin Clin Nutr Metab Care May;20(3):175-180.

- Bruhat A, Chaveroux C, Carraro V, Jousse C, Averous J, Maurin AC, Parry L, Mesclon F, Muranishi Y, Baril P, Do Thi A, Ravassard P, Mallet J, Fafournoux P. [Tuning transgene expression with an artificial diet: a compelling resource in gene therapy]. 2017 Med Sci (Paris) Feb;33(2):136-139.

- Dumortier O, Roger E, Pisani DF, Casamento V, Gautier N, Lebrun P, Johnston H, Lopez P, Amri EZ, Jousse C, Fafournoux P, Prentki M, Hinault C, Van Obberghen E. Age-Dépendent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet-Induced Fetal Programming.  2017 Diabètes Mar;66(3):627-639.

- Revel A, Jarzaguet M, Peyron M-A, Papet I, Hafnaoui N, Migné C, Mosoni L, Polakof S, Savary-Auzeloux I, Rémond D and Dardevet D. At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs.2017 Plos One.12(10):e0186204.

- Verney J, Martin V, Ratel S, Chavanelle V, Bargetto M, Etienne M, Chaplais E, Le Ruyet P, Bonhomme C, Combaret L, Guillet C, Boisseau N, Sirvent P and Dardevet D. Soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not improve muscle functional property restoration. 2017 Journal of Nutrition, Health and Aging.21(10):1133-1141.


- Aniort J, Polge C, Claustre A, Combaret L, Béchet D, Attaix D, Heng A-E, Taillandier D. Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury. 2016 International Journal of Biochemistry and Cell Biology.- PubMed

- Averous J, Lambert-Langlais S, Mesclon F, Carraro V, Parry L, Jousse C, Bruhat A, Maurin AC, Pierre P, Proud CG, Fafournoux P. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. 2016 Scientific Reports - PubMed

- Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice. Deval C, Capel F, Laillet B, Polge C, Béchet D, Taillandier D, Attaix DCombaret L. J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):587-603. doi: 10.1002/jcsm.12103. Epub 2016 Feb 15.

- Lower skeletal muscle capillarization in hypertensive elderly men. Gueugneau M, Coudy-Gandilhon C, Meunier B, Combaret L, Taillandier D, Polge C, Attaix D, Roche F, Féasson L, Barthélémy JC, Béchet D. Exp Gerontol. 2016 Apr;76:80-8. doi: 10.1016/j.exger.2016.01.013. Epub 2016 Jan 28.

- Bretin A, Carriere J, Dalmasso G, Bergougnoux A, B'Chir W, Maurin AC, Muller S, Seibold F, Barnich N, Bruhat A, Darfeuille-Michaud A, Nguyen HTT. Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. 2016 Autophagy;12(5):770-83. - PubMed

- Gietzen DW, Anthony TG, Fafournoux P, Maurin A-C, Koehnle TJ, Hao S. Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing. 2016 Cell Reports. 16(8):2049-50.- PubMed

- Polge C, Koulmann N, Claustre A, Jarzaguet M, Serrurier B, Combaret L, Béchet D, Bigard X, Attaix D, Taillandier D. UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension. 2016 International Journal of Biochemistry and Cell Biology. - PubMed

- Polge C, Leulmi R, Jarzaguet M, Claustre A, Combaret L, Bechet D, Heng AE, Attaix D, Taillandier D. UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes. 2016 J Caxhexia Sarcopenia Muscle. 7(3):377-87 - PubMed

- Pouget M, Perrot M, Denis P, Vuichoud J, Dardevet D, Vidal K, Breuille D, Papet I. Long-term dietary supplementation with cystathionine improves tissue glutathione in ageing rats. 2016 Aging clinical and experimental research. 28(4):781-5. Epub 2015/10/31. - PubMed