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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Our recent publications


Original publications and Reviews 2023

Habanjar O, Maurin AC, Vituret C, Vachias C, Longechamp L, Garnier C, Decombat C, Bourgne C, Diab-Assaf M, Caldefie-Chezet F, Delort L. A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization. Biomater Sci. 2023 Mar 22. doi: 10.1039/d2bm01470j. Epub ahead of print. PMID: 36946175.

Boungou-Tsona G, Gainche M, Decombat C, Ripoche I, Bikindou K, Delort L, Caldefie-Chézet F, Loumouamou A, Chalard P. Chemical Profile, Antioxidant and Anti-Inflammatory Potency of Extracts of Vitex madiensis Oliv. and Crossopteryx febrifuga (Afzel ex G. Don). Plants (Basel). 2023 Jan 13;12(2):386. doi: 10.3390/plants12020386. PMID: 36679099; PMCID: PMC9864984.

Cholet J, Decombat, C.; Delort, L.; Gainche, M.; Berry, A.; Ogeron, C.; Ripoche, I.; Vareille-Delarbre, M.; Vermerie, M.; Fraisse, D.; et al. Potential Anti-Inflammatory and Chondroprotective Effect of Luzula sylvatica. Int. J. Mol. Sci. 2023, 24, 127. ijms24010127

Habanjar, O.; Bingula, R.; Decombat, C.; Diab-Assaf, M.; Caldefie-Chezet, F.; Delort, L. Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment. Int. J. Mol. Sci. 2023, 24, 4002.

Nehme, R.; Chervet, A.; Decombat, C.; Longechamp, L.; Rossary, A.; Boutin, R.; Rousset, A.; Senejoux, F.; Vachias, C.; Auxenfans, C.; et al. Aspalathus linearis (Rooibos) Targets Adipocytes and Obesity-Associated Inflammation. Nutrients 2023, 15, 1751. https://

Original publications and Reviews 2022

Habanjar, O.; Diab-Assaf, M.; Caldefie-Chezet, F.; Delort, L. The Impact of Obesity, Adipose Tissue, and Tumor Microenvironment on Macrophage Polarization and Metastasis. Biology 2022, 11, 339.

Cholet J, Decombat C, Vareille-Delarbre M, Gainche M, Berry A (2022) Anti-Inflammatory and Antioxidant Activity of an Extract of Luzula sylvatica in a Co-Culture Model of Fibroblasts and Macrophages. Curr Res Cmpl Alt Med 6: 152. DOI:10.29011/2577-2201.100052

Nehme, R.; Diab-Assaf, M.; Decombat, C.; Delort, L.; Caldefie-Chezet, F. Targeting Adiponectin in Breast Cancer. Biomedicines 2022, 10, 2958. https://

Ennequin G, Delrieu L, Rossary A, Jacquinot Q, Mougin F, Thivel D, Duclos M. There is a need for a complete consideration of overall movement behaviors for the prevention, treatment, and follow-up of cancer risks and patients. Front Public Health. 2022 Dec 19;10:1080941. doi: 10.3389/fpubh.2022.1080941. PMID: 36600945; PMCID: PMC9806166.

Wauquier F, Boutin-Wittrant L, Bouvret E, Le Faouder J, Roux V, Macian N, Pickering G, Wittrant Y. Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications. Nutrients. 2022 Nov 25;14(23):5027. doi: 10.3390/nu14235027. PMID: 36501057; PMCID: PMC9737122.

Villatte G, Erivan R, Descamps S, Arque P, Boisgard S, Wittrant Y. In vitro osteoblast activity is decreased by residues of chemicals used in the cleaning and viral inactivation process of bone allografts. PLoS One. 2022 Oct 10;17(10):e0275480. doi: 10.1371/journal.pone.0275480. PMID: 36215295; PMCID: PMC9550034.

Granel H, Bossard C, Collignon AM, Wauquier F, Lesieur J, Rochefort GY, Jallot E, Lao J, Wittrant Y. Osteogenic Effect of Fisetin Doping in Bioactive Glass/Poly(caprolactone) Hybrid Scaffolds. ACS Omega. 2022 Jun 21;7(26):22279-22290. doi: 10.1021/acsomega.2c01109. PMID: 35811886; PMCID: PMC9260777.

Milenkovic D, Capel F, Combaret L, Comte B, Dardevet D, Evrard B, Guillet C, Monfoulet LE, Pinel A, Polakof S, Pujos-Guillot E, Rémond D, Wittrant Y, Savary- Auzeloux I. Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging. Crit Rev Food Sci Nutr. 2022 Jun 22:1-26. doi: 10.1080/10408398.2022.2089870. Epub ahead of print. PMID: 35730212.

Aldekwer S, Goncalves-Mendes N, Bingula R, Martinroche G, Lanchais K, Rougé S, Farges MC, Rossary A, Diab-Assaf M, Vasson MP, Talvas J. 25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics. J Physiol Biochem. 2022 May;78(2):335-342. doi: 10.1007/s13105-021-00868-z. Epub 2022 Jan 5. Erratum in: J Physiol Biochem. 2022 Jan 24;: PMID: 34985728; PMCID: PMC8727486.

Gritsch L, Granel H, Charbonnel N, Jallot E, Wittrant Y, Forestier C, Lao J. Tailored therapeutic release from polycaprolactone-silica hybrids for the treatment of osteomyelitis: antibiotic rifampicin and osteogenic silicates. Biomater Sci. 2022 Apr 12;10(8):1936-1951. doi: 10.1039/d1bm02015c. PMID: 35258044.

Wauquier F, Boutin-Wittrant L, Pourtau L, Gaudout D, Moras B, Vignault A, Monchaux De Oliveira C, Gabaston J, Vaysse C, Bertrand K, Abrous H, Capuron L, Castanon N, Vauzour D, Roux V, Macian N, Pickering G, Wittrant Y. Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders. Nutrients. 2022 Apr 5;14(7):1511. doi: 10.3390/nu14071511. PMID: 35406124; PMCID: PMC9002571.

Original publications and Reviews 2021

Aldekwer, S.; Desiderio, A.; Farges, M.-C.; Rougé, S.; Le Naour, A.; Le Guennec, D.; Goncalves-Mendès, N.; Mille-Hamard, L.; Momken, I.; Rossary, A.; et al. Vitamin D Supplementation Associated with Physical Exercise Promotes a Tolerogenic Immune Environment without Effect on Mammary Tumour Growth in C57BL/6 Mice. Eur J Nutr 2021, 60, 2521–2535.

Bouchara, N.; Senejoux, F.; Fraisse, D.; Felgines, C.; Caldéfie-Chezet, F.; Vasson, M.-P.; Madani, K.; Rossary, A. Anti-Inflammatory and Prolonged Protective Effects of Artemisia Herba-Alba Extracts via Glutathione Metabolism Reinforcement. South African Journal of Botany 2021, 142, 206–215.

Bourdier, P.; Birat, A.; Rochette, E.; Doré, É.; Courteix, D.; Dutheil, F.; Pereira, B.; Ratel, S.; Merlin, E.; Duché, P. Muscle Function and Architecture in Children with Juvenile Idiopathic Arthritis. Acta Paediatr 2021, 110, 280–287.

Delort, L.; Cholet, J.; Decombat, C.; Vermerie, M.; Dumontet, C.; Castelli, F.A.; Fenaille, F.; Auxenfans, C.; Rossary, A.; Caldefie-Chezet, F. The Adipose Microenvironment Dysregulates the Mammary Myoepithelial Cells and Could Participate to the Progression of Breast Cancer. Front. Cell Dev. Biol. 2021, 8, 571948.

Febvey-Combes, O.; Jobard, E.; Rossary, A.; Pialoux, V.; Foucaut, A.-M.; Morelle, M.; Delrieu, L.; Martin, A.; Caldefie-Chézet, F.; Touillaud, M.; et al. Effects of an Exercise and Nutritional Intervention on Circulating Biomarkers and Metabolomic Profiling During Adjuvant Treatment for Localized Breast Cancer: Results From the PASAPAS Feasibility Randomized Controlled Trial. Integr Cancer Ther 2021, 20.

Gainche, M.; Ogeron, C.; Ripoche, I.; Senejoux, F.; Cholet, J.; Decombat, C.; Delort, L.; Berthon, J.-Y.; Saunier, E.; Caldefie Chezet, F.; et al. Xanthine Oxidase Inhibitors from Filipendula Ulmaria (L.) Maxim. and Their Efficient Detections by HPTLC and HPLC Analyses. Molecules 2021, 26, 1939.

Lécuyer, L.; Victor Bala, A.; Demidem, A.; Rossary, A.; Bouchemal, N.; Triba, M.N.; Galan, P.; Hercberg, S.; Partula, V.; Srour, B.; et al. NMR Metabolomic Profiles Associated with Long-Term Risk of Prostate Cancer. Metabolomics 2021, 17, 32.

Wauquier, F.; Boutin-Wittrant, L.; Viret, A.; Guilhaudis, L.; Oulyadi, H.; Bourafai-Aziez, A.; Charpentier, G.; Rousselot, G.; Cassin, E.; Descamps, S.; et al. Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial. Nutrients 2021, 13, 2653.

Original publications and Reviews 2020

Grand, A.; Rochette, E.; Dutheil, F.; Gozal, D.; Calcaterra, V.; Berni Canani, R.; Cobanoglu, N.; Derikx, J.P.M.; Terrin, G.; Pereira, B.; et al. Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis. JCM 2020, 9, 857.

Jennotte, O.; Koch, N.; Lechanteur, A.; Evrard, B. Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: A review. Int J Pharm 2020, 580, 119200.

Kleinnijenhuis, A.J.; van Holthoon, F.L.; Maathuis, A.J.H.; Vanhoecke, B.; Prawitt, J.; Wauquier, F.; Wittrant, Y. Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption. Anal Bioanal Chem 2020, 412, 973–982.

Le Guennec, D.; Rossary, A. The interrelationship between physical activity and metabolic regulation of breast cancer progression in obesity via cytokine control. Cytokine Growth Factor Rev. 2020, 52, 76–87, doi:10.1016/j.cytogfr.2020.02.001.

Lécuyer, L.; Dalle, C.; Micheau, P.; Pétéra, M.; Centeno, D.; Lyan, B.; Lagree, M.; Galan, P.; Hercberg, S.; Rossary, A.; et al. Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort. Eur J Nutr 2020.

Ourhzif, E.-M.; Decombat, C.; Abrunhosa-Thomas, I.; Delort, L.; Khouili, M.; Akssira, M.; Caldefie-Chezet, F.; Chalard, P.; Troin, Y. Synthesis and biological evaluation of new naphthoquinones derivatives. Curr Org Synth 2020.

Pegon, C.; Rochette, E.; Rouel, N.; Pereira, B.; Doré, E.; Isfan, F.; Grèze, V.; Merlin, E.; Kanold, J.; Duché, P. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study. J Clin Med 2020, 9.

Vial, G.; Coudy-Gandilhon, C.; Pinel, A.; Wauquier, F.; Chevenet, C.; Béchet, D.; Wittrant, Y.; Coxam, V.; Soubrier, M.; Tournadre, A.; et al. Lipid accumulation and mitochondrial abnormalities are associated with fiber atrophy in the skeletal muscle of rats with collagen-induced arthritis. Biochim Biophys Acta Mol Cell Biol Lipids 2020, 1865, 158574.

Original publications and Reviews 2019

Bourdier, P., Saidi, O., Rochette, E., Ratel, S., Merlin, E., Pereira, B., Duché, P., 2019. Physical activity and sedentary levels in children with juvenile idiopathic arthritis and inflammatory bowel disease. A systematic review and meta-analysis. Pediatr. Res. 86, 149–156.

Cholet, J., Decombat, C., Vareille-Delarbre, M., Gainche, M., Berry, A., Senejoux, F., Ripoche, I., Delort, L., Vermerie, M., Fraisse, D., Felgines, C., Ranouille, E., Berthon, J.-Y., Priam, J., Saunier, E., Tourrette, A., Troin, Y., Thebaud, G., Chalard, P., Caldefie-Chezet, F., 2019. In Vitro Anti-Inflammatory and Immunomodulatory Activities of an Extract from the Roots of Bupleurum rotundifolium. Medicines (Basel) 6.

Goncalves-Mendes, N., Talvas, J., Dualé, C., Guttmann, A., Corbin, V., Marceau, G., Sapin, V., Brachet, P., Evrard, B., Laurichesse, H., Vasson, M.-P., 2019. Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial. Front Immunol 10, 65.

Jiménez-García, K., Invernizzi, A., Evrard, B., Frapolli, C., Dalibard, J., Gerbier, F., 2019. Spontaneous formation and relaxation of spin domains in antiferromagnetic spin-1 condensates. Nat Commun 10, 1422.

Lécuyer, L., Dalle, C., Lyan, B., Demidem, A., Rossary, A., Vasson, M.-P., Petera, M., Lagree, M., Ferreira, T., Centeno, D., Galan, P., Hercberg, S., Deschasaux, M., Partula, V., Srour, B., Latino-Martel, P., Kesse-Guyot, E., Druesne-Pecollo, N., Durand, S., Pujos-Guillot, E., Touvier, M., 2019. Plasma Metabolomic Signatures Associated with Long-term Breast Cancer Risk in the SU.VI.MAX Prospective Cohort. Cancer Epidemiol. Biomarkers Prev. 28, 1300–1307.

Rochette, E., Bourdier, P., Pereira, B., Doré, E., Birat, A., Ratel, S., Echaubard, S., Duché, P., Merlin, E., 2019a. TNF blockade contributes to restore lipid oxidation during exercise in children with juvenile idiopathic arthritis. Pediatr Rheumatol Online J 17, 47.

Vareille-Delarbre, M., Miquel, S., Garcin, S., Bertran, T., Balestrino, D., Evrard, B., Forestier, C., 2019. Immunomodulatory Effects of Lactobacillus plantarum on Inflammatory Response Induced by Klebsiella pneumoniae. Infect. Immun. 87.

Publications for ECREIN Team on Pubmed (Full list)