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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Muscle lipotoxicity

Muscle lipotoxicity
Characterization of the mechanisms responsible for lipotoxicity establishment and its impact on the development of sarcopenia. Exploration of the skeletal muscle - adipose tissue crosstalk.

The basic exploration regarding the development of muscle anabolic resistance aims to identify regulating mediators of the adipose tissue-muscle crosstalk (lipids, proteins carried out by extracellular vesicles). The role of secreted proteins and of extracellular vesicles implicated in the interorgan communication between adipose tissue and muscle metabolism and the modulatory effect of nutrients (AA, PUFA, Vitamin D…) is investigated using both in vitro and in vivo lipidomic and proteomic approaches. Others mediators derived from lipids may contribute to muscle loss during aging as suggested by recent results from our lab demonstrating a potential role of the endocannabinoids (EC), molecules derived from polyunsaturated FA. Further investigations are exploring the link between EC, ectopic accumulation of lipids in skeletal muscle, anabolic resistance and loss of muscle mass/function ("Canabolism" project). A subtopic of the program focuses on the contribution of mitochondrial alterations in lipotoxicity onset and related muscle dysfunctions. Moreover, different models are used to analyze the metabolic consequences of vitamin D deficiency on muscle mitochondrial oxidative functions and lipotoxicity during aging by the combination of in vitro and in vivo approaches. The impact of mitochondria dysfunction on muscle lipotoxicity is also investigated in myocardium and during chronic diseases such as cancer cachexia, or inflammatory disorders.