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INRA
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31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Multimodal targeted preventive and therapeutic strategies.

Multimodal targeted preventive and therapeutic strategies.
Development of integrated multimodal approaches to limit sarcopenia during aging and chronic diseases

Beside the study of new signaling pathways involved in muscle alterations during aging and chronic diseases, the team will establish interventional and targeted strategies to counteract the processes that we and others have identified.
We contributed to demonstrate the beneficial effects of long chain omega 3 FA against lipotoxicity, inflammation and anabolic resistance. We will then go ahead to analyze the differential effects of various fatty acids (short chain vs long chain, saturated vs unsaturated, ω6 vs ω3) on the rate and regulation of protein synthesis in muscle cells and animal models of depletion/repletion. We also explore the transgenerational protective effects of omega-3 in mice. The preventive effect of ω3 FA on muscle lipotoxicity, mitochondrial dysfunction and anabolic resistance in the context of chronic inflammation will be studied in combination with specific cytokine and JAK inhibitors in a rodent model of rheumatoid arthritis ("Lipoxar" project).

In addition to lipid intakes, the optimization of food protein intakes is essential to fight against lipotoxicity and anabolic resistance to limit sarcopenia. Considering the expertise of the team in the identification of protein sources and their effects on skeletal muscle health, we will continue our projects on food sources of amino acids which could have a beneficial effect during aging or chronic diseases. The team keeps its historical involvement in the definition of protein requirements in specific populations, and especially to prevent sarcopenic obesity. As an example, clinical research project aims to determine amino acid bioavailability of milk proteins before and after bariatric surgery and to compare the efficiency of whole dietary proteins vs hydrolyzed proteins. A particular interest appears for new protein sources such as vegetables and algae that are low-fat and micronutrients-rich food. The essential amino acid composition, the bioavailability as well as the digestibility of plant-based proteins will then be evaluated in models of aged rats as well as in humans ("Germleg" project).

Multimodal approaches including the combination of a nutritional strategy and physical activity should also be considered to improve mitochondrial function, protein synthesis and reduce muscle lipotoxicity. Eccentric exercise allows a greater muscle force development/energy cost ratio and is a modality of choice for patients with muscular limitations during chronic pathologies and/or ageing. New eccentric exercise protocols in association to nutritional supplement (vitamin D, fast digestive proteins) will be established in rodent’s model and mitochondrial function, energetic substrate consumption and protein synthesis will be respectively assessed.