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Dernière mise à jour : Mai 2018

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Human Nutrition Unit

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ASMS News

RH: The ASMS team is expanding…

The ASMS team is growing, as 2 new PhD students have joined our ranks. It is with pleasure that we welcome

Lisa Guerrier. Lisa holds a Master's degree in "Nutrition Health Innovation, Human Health Nutrition" (UCA). She obtained a funding from the Doctoral School of UCA. She is starting a thesis on the Role of mitochondria in human adipose tissue in the context of body composition modification during chronic diseases. This work is supervised by Ruddy Richard and Corinne Malpuèch-Brugère.

Thesis summary

Mitochondria play a key role in the maintenance of energy homeostasis in tissues including adipose tissue. If quantitative (number of mitochondria) or qualitative mitochondrial dysfunctions have been well studied in human skeletal muscle tissue, they are poorly documented in adipose tissue, especially depending on the origin and location (subcutaneous or visceral epiplonic adipose tissue). A key role of adipose tissue mitochondria is increasingly suggested in the development of metabolic diseases, notably obesity (fat mass gain), type 2 diabetes and cancer (fat mass loss). The hypothesis is that mitochondrial dysfunction could lead to adverse effects on adipocyte differentiation, lipid metabolism, insulin sensitivity, oxidative capacity and thermogenesis. The objective of this thesis will be to characterize the function of mitochondria according to the origin of subcutaneous and visceral adipose tissue in patients with metabolic dysfunctions, and thus to understand the impact of weight gain or loss on the metabolic activity of these tissues.

Aurélien Brun. Aurélien holds a Master's degree in "Nutrition Health Innovation, Human Health Nutrition" (UCA). He obtained a funding from Clermont Auvergne Métropole. He is starting his thesis on the Prevention of muscle atrophy and myosteatosis by omega-3 fatty acids. This work is supervised by Fédéric Capel and Vera Mazurak. Aurélien will complete half of his thesis in the ASMS team and the other half at the University of Alberta (Canada).

Thesis summary

Healthy aging has become a major societal issue due to the current demographic dynamics of Western countries. Periods of chronic or acute loss of muscle capital lead to an increase in the length of hospitalization and a deterioration in the prognosis of weakened individuals. This is why maintaining muscle mass is one of the main determinants of autonomy in aging people. During my PhD in collaboration with INRAe/UCA & Cross Cancer Institute/UofA, I am interested in the fundamental biological processes leading to the accumulation of toxic lipids in the muscle called myosteatosis. The objective is to understand how and why long-chain unsaturated fatty acids of marine origin allow to preserve the integrity of the muscle during episodes of acute lipotoxicity occurring in many pathological conditions (Cancer, Diabetes, Obesity, Rheumatoid Arthritis).

Publications

Publications

Last publication of ASMS
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Conferences

Conferences

Scientific Conferences, Seminary, Phd Defenses
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