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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Diet, Muscle Health and Sarcopenia

Team leader : Yves BOIRIE

Topics and Objectives

Aging is associated with a gradual loss of physiological functions and functional abilities of the body. The musculo-skeletal system is more particularly affected by aging and its alterations result in a decrease muscle mass/function, called sarcopenia. The gradual loss of mobility that results from this sarcopenia promotes the development of metabolic syndrome, sedentary lifestyle, and increased risk of falls. Furthermore, a low skeletal muscle mass/strength is a predictor of morbidity and mortality. Therefore, prevention of muscle loss in aging is critical to maintain physical abilities at an advanced age and to optimize the quality of life of the aged people.

The ASMS team has a long research tradition on skeletal muscle, protein / energy metabolisms and dietary lipids/ proteins, with specific emphasis on the crosstalk between skeletal muscle and adipose tissue. The research programs of the team mainly focus on the impact of the aging process and chronic diseases on muscle anabolic responses and impaired metabolisms.

The objective of the team focus on the preservation of mobility through new strategies involving nutrition and physical activity to improve muscle function and prevent sarcopenia-related comorbidities. We developed expertise in 1) molecular mechanisms of skeletal muscle loss, 2) interactions between skeletal muscle and body or ectopic adiposity, 3) specific and synergistic actions of food/nutrients and physical activity on muscle mass, metabolism and function, 4) clinical research and investigations on sarcopenia in ageing and chronic diseases.

We are focusing our research on the following topics:

1. Muscle lipotoxicity as a key characteristic of sarcopenia by exploring adipose tissue-muscle crosstalk and mitochondrial function.

2. Multimodal targeted preventive and therapeutic strategies to limit sarcopenia development during aging and chronic diseases.

3. Molecular, phenotypic or behavioral signatures of sarcopenia to help its diagnosis and management.

Keywords

Food
Physical activity - Mobility
Clinical and animal studies
Skeletal muscle mass and functions
Inflammation - Lipotoxicity
Chronic and metabolic diseases
insulin resistance - Oxidative stress
Sarcopenia - Aging