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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Dr Laurent-Emmanuel MONFOULET

Researcher (PhD)

Mechanism of action of Polyphenols modulating the vascular function

	Key Words: Extracellular Vesicles Polyphenols Vascular endothelial function	Contact Email : laurent-emmanuel.monfoulet[at]inrae.fr Phone : +33(0)4 73 62 42 90

Research Extracellular vesicles (EVs) emerge as a hot topic in biology 1/ since their circulating level has been identified as modulated by nutritional stress and cardiometabolic disorders. Nutritional preventive strategies based on plant foods are good candidates to promote health. Their success is based on the exclusive plant source of bioactive compounds, including especially polyphenols, for which a regular consumption is associated with a reduced risk of these diseases. My current projects aim at demonstrating the ability of polyphenols to modulate EVs from vascular endothelium and the contribution of these EVs to prevent vascular dysfunction. Ongoing Projects : Extracellular Vesicles and their content in miRNA: tissular specificity and indicator of pathophysiological status? (projet aVEmiR - iSite Clermont 2019).

Publications Nikolic M, Konic Ristic A, González-Sarrías A, Istas G, Urpi-Sarda M, Dall'Asta M, Monfoulet LE, Cloetens L, Bayram B, Tumolo MR, Chervenkov M, Scoditti E, Massaro M, Tejera N, Abadjieva D, Chambers K, Krga I, Tomás-Barberán FA, Morand C, Feliciano R, García-Villalba R, Garcia-Aloy M, Mena P. Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations.Eur J Nutr. 2019 Sep 6. doi: 10.1007/s00394-019-02069-3 Morand,N. Barber‐Chamoux, L‐E Monfoulet, D. Milenkovic. Dietary (Poly)Phenols and Vascular Health.C. Recent Advances in Polyphenol Research, Volume 6. Book Editor(s):H. Halbwirth,K.Stich,V. Cheynier, S. Quideau. First published: 11 January 2019https://doi.org/10.1002/9781119427896.ch5 Monfoulet LE, Mercier S, Bayle D, Tamaian R, Barber-Chamoux N, Morand C, Milenkovic D. Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics. Free Radic Biol Med. 2017 Nov;112:109-120. doi: 10.1016/j.freeradbiomed.2017.07.019. Krga I, Milenkovic D, Morand C, Monfoulet LE. An update on the role of nutrigenomic modulations in mediating the cardiovascular protective effect of fruit polyphenols. Food Funct. 2016 Sep 14;7(9):3656-76. doi: 10.1039/c6fo00596a. Krga I, Monfoulet LE, Konic-Ristic A, Mercier S, Glibetic M, Morand C,Milenkovic D. Anthocyanins and their gut metabolites reduce the adhesion of,monocyte to TNFα-activated endothelial cells at physiologically relevant concentrations. Arch Biochem Biophys. 2016 Jun 1;599:51-9. doi:10.1016/j.abb.2016.02.006. Monfoulet LE, Philippe C, Mercier S, Coxam V, Wittrant Y (2015). Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis. Experimental biology and Medicine [Epub ahead of print] (IF:2.165; Medicine, Research and Experimental 67/123; Q3) Mével E, Monfoulet LE, Merceron C, Coxam V, Wittrant Y, Beck L, Guicheux J (2014). Nutraceuticals in joint health: animal models as instrumental tools. Drug Discovery Today 19(10):1649-58 (IF: 6.691; Pharmacology and Pharmacy 12/254; Q1) ( : co-premier auteur) Monfoulet LE, Becquart P, Marchat D, Vandamme K, Bourguignon M, Pacard E, Viateau V, Petite H, Logeart-Avramoglou D. (2014) The pH in the microenvironment of human mesenchymal stem cells is a critical factor for optimal osteogenesis in tissue-engineered constructs. Tissue engineering 20, 1827-1840. [IF:4,254 ; Cell & Tissue Engineering 5/18 ; Q2] Becquart P, Cambon-Binder A, Monfoulet LE, Bourguignon M, Vandamme K, Bensidhoum M, Petite H, Logeart-Avramoglou D. (2012) Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo. Tissue engineering 18, 2084-2094. [IF:4,254 ; Cell and Tissue Engineering 5/18 ; Q2] Monfoulet LE, Rabier B, Dacquin R, Anginot A, Photsavang J, Jurdic P, Vico L, Malaval L, Chassande O. (2011) Thyroid hormone receptor beta mediates thyroid hormone effects on bone remodeling and bone mass. J Bone Miner Res 26, 2036-2044. [IF: 6,589; Endocrinology and metabolism 12/124; Q1]

Grant & Awards Grants: "Syngergy of polyphenols together with PUFA (omega 3) on oxylipin metabolism in endothelial cells" - Funding by 'Groupes Lipides Nutrition' (2017-2018)- Coordination with Cécile Gladine (INRA -UNH) Effects of oregonin, a bioactive compound from black alder, on the epigenetic marks in endothelial cells: Involvement in endothelial dysfunction preservation? - - COST POSITIVe - in collaboration with Pr. J. Krasilnikova (Riga Stradins University, Latvia), Pr. G. Telysheva (Professor, Latvian State Institute of Wood chemistry, Latvia) and Pr. E. Kistanova (Institute of biology and immunology of reproduction, Bulgaria)(Patent P19-25, LV) "In silico prediction of interplays between flavanone metabolites and cell signalling-modulators in the vasculo-protective effect of polyphenols" (2017)- Funding COST POSITIVe FA1403 - Coordination, in collaboration with Jasna KLICIC BADOUX (NIHS, Suisse) Action COST POSITIVe (FA 1403) « Main determinants of interindividual variability in response to the consumption of plant food bioactives linked to cardiometabolic protection » - Co-leader of the Think Tank Group - Task leader in WG2 - POSITIVe Webmaster Awards: Food & Function award - 1st int. conference on Food bioactives and health (2016) Best paper Award 2016 - Society for Experiemental Biology and Medicine Oral communication award "sphérulites CHOL-TOE-BP : un système microvésiculaire de délivrance osseux" 11eme JFBTM 2009

Curriculum Vitae Since 2013: Researcher at INRA UMR 1019 - Team "Diet, Plant Food Bioactives and Vascular Health" 2011-2013 : Researcher at INRA UMR 1019 - Team "Diet, metabolism and skeleton" 2009-2011 : Post-Doctoral training at Paris Diderot University/CNRS, Joint Research Unit U7052 "Osteoarticular Bioengineering and Bioimmaging" 2006-2009 : PhD, Cellular Biology and physiopathology. Bordeaux University (France)