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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

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Human Nutrition Unit

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Activité de recherche



Email : contact
Tel : +33(0)4 73 62 48 95

Research Activity       Publications       Curriculum Vitae

The demographic evolution on western countries is characterised by an increase in aging and longevity of the population. Aging is associated with metabolic alterations that could appear more or less rapidly and that will lead to pathophysiological conditions like insulin resistance, diabetes or obesity.

The metabolism must constantly adapt to these environmental conditions and remain flexible to maintain the whole body homeostasis and health. Among the environmental factors we can cite the nutrition and the daily handling of nutrients. The western countries are characterised by an important intake of high energy and high fat/sugar diets, known to be deleterious for body health. However, the adaptation mechanisms and the events associated to the loss of flexibility of the metabolisms remains poorly known. This is particularly important, as they precede the installation of the pathological phenotype on which the final diagnosis is currently established. My research project aims to understand the mechanisms allowing to anticipate the onset of the metabolic pathologies and to elaborate early nutritional strategies able to prevent these metabolic perturbations.

Activités de recherche

The main objective of my research is to better understand the events participating to the metabolic flexibility (or nutritional allostasis) and to study the time-course changes of the metabolic phenotypes leading to the pathologies (metabolic trajectories) using a integrative approach, from the whole body to the target tissues, using open (as metabolomics and transcritptomics) but also targeted (substrates, enzyme activity) approaches. My studies are focussed on the development of a post-prandial anabolic resistance, a common component of many pathophysiological situations associated with aging, and that includes changes in insulin sensitivity but also nutrient utilisation and signalling. I utilise classic animal models of nutritionally-induced obesity (high fat/high fructose diet), like rodents, but also minipigs. The latter offers a significant similarity with human physiology and nutrition and has an important technical potential, including time-course studies and the access to several biological compartments allowing inter-organ studies.

I also interested on studies aiming to understand the interaction between nutrients and the metabolic crossroads allowing explaining the perturbations and regulations of the amino acids metabolism during pathology onset. On this context, lipids seem to be involved on the elevated blood levels of one particular kind of amino acids observed during obesity onset: the branched-chain amino acids. On the other hand, some carbohydrates, like fructose, might have a sparing impact on body proteins and amino acids during catabolic states, instead a deleterious role, as observed during high-fructose feeding diets.

Dr Sergio POLAKOF Publications

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Dr Sergio POLAKOF Curriculum Vitae

Curriculum Vitae
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