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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Dr Didier REMOND Publications


Dr Didier REMOND 


Email : contact
Tel : +33(0)4 73 62 40 74


  Research Activities       Publications       Curriculum Vitae


Polakof S, Rémond D, David J, Dardevet D, Savary-Auzeloux I, 2018. Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig. Nutrition 50:66-73.

Mohamed AB, Rémond D, Chambon C, Sayd T, Hebraud M, Capel F, Cohade B, Hafnaoui N, Bechet D, Coudy-gandilhon C, Migné C, David J, Dardevet D, Doré J, Polakof S, Savary-auzeloux I, 2019. A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs. Journal of Nutritional Biochemistry.  65:72-82.

Jarzaguet M, Polakof S, David J, Migné C, Joubrel G, Efstathiou T, Rémond D, Mosoni L, Dardevet D, 2018. A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the age-related muscle anabolic resistance only if the protein content and leucine levels are increased. Food and Functions, 9(12):6526-6534

Zeng Y, David J, Rémond D, Dardevet D, Savary-Auzeloux I, Polakof S, 2018. Peripheral blood mononuclear cells metabolism adapted acutely to the postprandial transition and reflected mainly the adipose tissue metabolic adaptations to a high fat fed diet in minipigs. Nutrients, 10(11) pii: E1816

Margier M, Georgé S, Hafnaoui N, Rémond D, Nowicki M, Du Chaffaut L, Amiot-Carlin MJ, Reboul E, 2018. Nutritional composition and bioactive content of legumes: characterization of pulses frequently consumed in France and effect of the cooking method. Nutrients, 10(11) pii: E1668.

Gatineau E, Cluzet S, Krisac S, Papet I, Migne C, Rémond D, Dardevet D, Polakof S, Richard T, Mosoni L, 2018. Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and other micronutrients. Journal of Physiology and Biochemistry, 74(4): 569-577.

Gatineau E, Cluzet S, Krisa S, Papet I, Migné C, Rémond D, Dardevet D, Polakof S, Richard T, Mosoni L, 2018. Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats, Modulation by rutin and other micronutrients. Food and functions, 9(5):2922-2930

Margier M, Buffière C, Goupy P, Rémond D, Halimi C, Caris C, Borel P, Reboul E, 2018. Opposite effects of the spinach food matrix on lutein bioaccessibility and intestinal uptake lead to unchanged bioavailability compared to pure lutein. Molecular Nutrition & Food Research, 62(11):e1800185

Sayd T, Dufour C, Chambon C, Buffière C, Rémond D, Santé-Lhoutellier V, 2018. Combined in vivo and in silico approaches for predicting the release of bioactive peptides from meat digestion. Food Chem, 249:111-118.

Dufour C, Loonis M, Delosière M, Buffière C, Hafnaoui N, Santé-Lhoutellier V, Rémond D, 2018. The matrix of fruit & vegetables modulates the gastrointestinal bioaccessibility of polyphenols and their impact on dietary protein digestibility. Food Chem, 240:314-322.

Revel A, Jarzaguet M, Peyron MA, Papet I, Hafnaoui N, Migné C, Mosoni L, Polakof S, Savary-Auzeloux I, Rémond D, Dardevet D, 2017. At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient postprandial muscle anabolic response during a catabolic state in mini pigs. PloS One 12(10):e0186204.

Buffière C, Gaudichon C, Hafnaoui N, Migné C, Scislowsky V, Khodorova N, Mosoni L, Blot A, Boirie Y, Dardevet D, Santé-Lhoutellier V, Rémond D, 2017. In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done. Am J Clin Nutr, 106(5):1257-1266

Mast C, Pourpe C, Voyard G, Rémond D, Migné C, Centeno D, Dardevet D, Savary-Auzeloux I, Papet I, 2017. Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats. Br J Nutr 118(11):889-896.

Mast C, Savary-Auzeloux I, Rémond D, Pouyet C, Centeno D, Voyard G, Combaret L, Dardevet D & Papet I, 2016. Repeated cures with paracetamol worsen sarcopenia in old rats with suboptimal food intake. J Physiol Pharmacol, 67(5):759-768.

Borel P, Desmarchelier C, Dumont U, Halimi C, Lairon D, Page D, Sébédio JL, Buisson C, Buffière C, Rémond D, 2016. Dietary calcium impairs tomato paste lycopene bioavailability in healthy humans. British Journal of Nutrition, 116(12):2091-2096.

Seiliez I, Belghit I, Gao Y, Skiba-Cassy S, Dias K, Cluzeaud M, Rémond D, Hafnaoui N, Salin B, Camougrand N, Panserat S, 2016. Looking at the limits of in vivo autophagic flux assays. Autophagy 12:343-356.

Théron L, Centeno D, Coudy-Gandilhon C, Pujos Guillot E, Astruc T, Rémond D, Barthélemy JC, Roche F, Feasson L, Hébraud M, Bechet D, Chambon C, 2016. A proof of concept to bridge the gap between mass spectrometry imaging, protein identification and relative quantitation: MSI-LC-MS/MS-LF. Proteomes 4:32; doi:10.3390/proteomes4040032

Delosière M, Santé-Lhoutellier V, Chantelauze C, Durand D, Thomas A, Joly C, Pujos-Guillot E, Rémond D, Comte B, Gladine C, Guy A, Durand T, Laurentie M, Dufour C, 2016. Quantification of 4-hydroxy-2-nonenal-protein adducts in the in vivo gastric digesta of mini-pigs using a GC-MS/MS method with accuracy profile validation. Food Funct 7(8):3497-504.

Polakof S, Rémond D, Bernalier-Donadille A, Rambeau M, Pujos-Guillot E, Comte B, Dardevet D, Savary-Auzeloux I, 2016.  Metabolic adaptations to HFHS overfeeding: How whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs. European Journal of Nutrition. DOI 10.1007/s00394-016-1302-1.

Buffière C, Mariotti F, Savary-Auzeloux I, Migné C, Meunier N, Hercberg S, Cano N, Rémond D, Duclos M, Dardevet D. 2015. Slight chronic elevation of C-reactive protein is associated with lower aerobic fitness but does not impair meal-induced stimulation of muscle protein metabolism in healthy old men. J Physiol 593(5):1259-72.

Polakof S, Rémond D, Rambeau M, Pujos-Estelle E, Sébédio JL, Dardevet D, Comte B, Savary-Auzeloux I, 2015. Postprandial metabolic events in mini-pigs: new insights from a combined approach using plasma metabolomics, tissue gene expression, and enzyme activity. Metabolomics 11:964-979.

Marsset-Baglieri A, Fromentin G, Nau F, Airinei G, Piedcoq J, Rémond D, Benamouzig R, Tomé D, Gaudichon C, 2015. The satiating effects of eggs or cottage cheese are similar in healthy subjects despite differences in postprandial kinetics. Appetite 90:136-143.

Oberli M, Marsset-Baglieri A, Airinei G, Santé-Lhoutellier V, Khodorova N, Rémond D, Foucault-Simonin A, Piedcoq J, Tomé D, Fromentin G, Benamouzig R, Gaudichon C, 2015. High True Ileal Digestibility but Not Postprandial Utilization of Nitrogen from Bovine Meat Protein in Humans Is Moderately Decreased by High-Temperature, Long-Duration Cooking. J Nutr 145:2221-8.

Barbé F, Ménard O, Le Gouar Y, Buffière C, Famelart MH, Laroche B, Le Feunteun S, Rémond D, Dupont D, 2014. Acid and rennet gels exhibit strong differences in the kinetics of milk protein digestion and amino acid bioavailability. Food Chem 143, 1-8.

Le Feunteun S, Barbé F, Rémond D, Ménard O, Le Gouar Y, Dupont D, Laroche B, 2014. Impact of the dairy matrix structure on milk protein digestion kinetics: mechanistic modelling based on mini-pig in vivo data. Food and Bioprocess Technology 7, 1099-1113.

Marsset-Baglieri A, Fromentin G, Airinei G, Pedersen C, Léonil J, Piedcoq J, Rémond D, Benamouzig R, Tomé D, Gaudichon C 2014. Milk proteins fractions moderately extend the duration of satiety compared to carbohydrates independently of their digestive kinetics in overweight subjects. Br J Nutr 112, 557-64.

Gobert M, Rémond D, Loonis M, Buffière C, Santé-Lhoutellier V, Dufour C, 2014. Fruits, vegetables and their polyphenols protect dietary lipids from oxidation during gastric digestion. Food and Funct 5, 2166-74.

Barbé F, Le Feunteun S, Rémond D, Ménard O, Jardin J, Henry G, Laroche B, Dupont D, 2014. Tracking the in vivo release of bioactive peptides in the gut during digestion: Mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs. Food Res Int 63,147-56.

Mast C, Joly C, Savary-Auzeloux I, Rémond D, Dardevet D, Papet I, 2014. Skeletal muscle wasting occurs in adult rats under chronic treatment with paracetamol (acetaminophen) when glutathione-dependent detoxification is highly activated. J Physiol Pharmacol 65(5):623-31.

Mosoni L, Gatineau E, Gatellier P, Migné C, Savary-Auzeloux I, Rémond D, Rocher E, Dardevet D, 2014. High whey protein intake delayed the loss of lean body mass in healthy old rats, whereas protein type and polyphenol/antioxidant supplementation had no effects. PlosOne 9(9):e109098.

Gallot YS, Durieux AC, Castells J, Desgeorges MM, Vernus B, Plantureux L, Rémond D, Jahnke VE, Lefai E, Dardevet D, Nemoz G, Schaeffer L, Bonnieu A, Freyssenet DG, 2014. Myostatin gene inactivation prevents skeletal muscle wasting in cancer. Cancer Res 74(24):7344-56.

Bax, M-L, Sayd T, Aubry,L, Ferreira C, Viala D, Chambon C, Rémond D, Santé-Lhoutellier V, 2013. Muscle composition slightly affects in vitro digestion of aged and cooked meat: identification of associated proteomic markers.  Food Chem 136, 1249-1262.

Bax ML, Buffière C, Hafnaoui N, Gaudichon C, Dardevet D, Santé-Lhoutellier V, Rémond D, 2013. Effects of meat cooking, and of ingested amount, on protein digestion speed and entry of residual proteins into the colon: a study in minipigs. PlosOne 8(4):e61252. doi: 10.1371/journal.pone.0061252.

Barbé F, Ménard O, Le Gouar Y, Buffière C, Famelart MH, Laroche B, Le Feunteun S, Dupont D Rémond D. 2013. The heat treatment and the gelation are strong determinants of the kinetics of milk proteins digestion and of the peripheral availability of amino acids. Food Chem 136, 1203-1212.

Magne H, Savary-Auzeloux I, Migné C, Peyron MA, Combaret L, Mosoni L, Rémond D, Dardevet, D, 2013. Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet. PlosOne 8(8):e70130. doi: 10.1371/journal.pone.0070130.

Savary-Auzeloux I, Magne H, Migné C, Oberli M, Breuillé D, Faure M, Williamson G, Combaret L, Rémond D, Dardevet D, 2013. Dietary supplementation in leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats. PlosOne 8(11):e81495. doi: 10.1371/journal.pone.0081495.



Bohn T, Carriere F, Day L, Deglaire A, Egger L, Freitas D, Golding M, Le Feunteun S,Macierzanka A, Menard O, Miralles B, Moscovici A, Portmann R, Recio I, Rémond D, Santé-Lhoutelier V, Wooster TJ, Lesmes U, Mackie AR, Dupont D, 2018. Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models? Crit Rev Nutr Food Sci 58(13):2239-2261.

Bordoni A, Danesi F, Dardevet D, Fernandez AS, Gille D, Nunes dos Santos C, Pinto P, Re R, Rémond D, Shahar D, Vergères G, 2017. Dairy Products and Inflammation: A Review of the Clinical Evidence. Crit Rev Food Sci Nutr 65(5):623-31.

Thorning TK, Bertram HC, Bonjour JP, de Groot L, Dupont D, Feeney E, Ipsen R, Lecerf JM, Mackie A, McKinley MC, Michalski MC, Rémond D, Risérus U, Soedamah-Muthu SS, Tholstrup T, Weaver C, Astrup A, Givens I, 2017. Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. Am J Clin Nutr 105(5):1033-1045.

Gorissen SH, Rémond D, van Loon LJ, 2015. The muscle protein synthetic response to food ingestion. Meat Sci 109:96-100.

Rémond D, Shahar DR, Gille D, Pinto P, Kachal J, PeyronMA, Nunes Dos Santos C, Walther B, Bordoni A, Dupont D, Tomas L, Vergères G, 2017. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. Oncotarget  6(16):13858-98.

Wester T, Kraft G D Dardevet, S Polakof, I Ortigues-Marty, D Rémond, I Savary- Auzeloux, 2015. Nutritional regulation of the anabolic fate of amino acids within the liver in mammals. Concepts arising from in vivo studies.  Nutrition Research Reviews 28(1):22-41.

Magne H, Savary-Auzeloux I, Rémond D, Dardevet D, 2013. Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery. Nut Res Rev 26(2):149-65.