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Last update: May 2021

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Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Didier Rémond

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Didier_REMOND

Research Activities       Publications       Curriculum Vitae

Research activities

According to INSEE projections, 1/3 of the French population will be over 60 in 2050. One of the features of ageing is sarcopenia, which is a physiological and involuntary loss of muscle mass and strength. This feature is common to all older individuals, including healthy ones, and is considered one of the most important causes of disability, frailty and morbidity. Preventing muscle mass and strength loss in elderly has thus become an important challenge in order to maintain their autonomy, health and welfare, but also to reduce public health care costs.

Age-related loss of muscle proteins can be worsen by a decreased arterial availability of nutrients. The amino acid bioavailability depends on the nature of ingested proteins and the food matrix in which they are, but also on the metabolic activity of the other body tissues competing with the muscle for their use. Among these competitors, tissues from the splanchnic area (gut and liver) play a key role. Any increased utilization of one or several amino acids by these organs will necessarily affect muscle protein anabolism. During the past ten years, my work in this area has been focused on the ‘Food matrix’ effect on nutrients bioavailability, and on the intestinal metabolism of specific amino acids (threonine et acides amines soufrés).

Up to 2050, the combined increase in world population, and standards of living in developing countries, will lead to a tremendous rise in the demand for food protein, especially animal-source protein (FAO, 2013). This demand cannot be met in a sustainable way by an increase in animal production, so that the use of alternative sources of protein must be considered.

Thus, my research program focuses now on the development of new protein food for overall or targeted populations (mainly seniors).To reach this goal, I currently work on the characterisation of the nutritional quality of alternative protein sources, on the impact of the technological processes associated with them, and finally on the validation of their health effects in human. As such, I am coordinating a national project on the valuing of plant proteins in blends of high nutritional quality, aiming at the prevention of metabolic dysregulations in the elderly population (ANR P-Probs).

PROFESSIONAL SKILLS

-  Human nutrition: protein quality evaluation (amino acid composition, digestibility, digestion rate, bioactive peptides), impact of food processing on protein quality, amino acid metabolism in the gut, inter-organ fluxes of amino acids.

-  Experimental approaches: in vivo studies in human or animals (pig, minipig, rat), focussing on quantitative and dynamics measurements of digestive and blood fluxes of nutrients: 1/ surgical implantation of digestive cannula, and vascular catheters, 2/ measurement of the digestive and blood fluxes, 3/ investigation of protein metabolism with metabolic tracers, 4/ use of 15N labelled protein sources.

Dr Didier REMOND Publications

Publications
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Dr Didier REMOND Parcours et Eléments de CV

Parcours et Eléments de CV
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