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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Dr Laetitia DELORT

Lecturer

Email : contact
Tel : +33(0)4 73 17 79 70

Field of Research

My research focuses on the interactions between mammary epithelial cells (immunocompetent barrier cells) and their microenvironment in the context of obesity. Indeed, obesity, which has reached epidemic proportions, making it one of the most important diseases of this century, is now recognized as a risk factor for a number of cancers such as breast cancer in postmenopausal women. My research work will therefore focus on identifying the role of the adipose microenvironment in the development of breast cancer pathology through the development of original culture models (2D and 3D). In addition, we are actively working to discover new bioactive compounds of plant origin that could play a role in these interactions.

Research Activities

Characterization of the interactions between immunocompetent cells and their microenvironment in the context of obesity

Understanding the interactions between mammary epithelial and adipose cells now seems crucial, especially in obese situations. Our research consists in characterizing this dialogue through the development of different models (monolayer culture, co-cultures and three-dimensional culture) using human epithelial cell lines as well as mature adipocytes extracted from normal or obese women allowing us to evaluate the proliferative activity and the mechanisms of action involved.

Research of immunomodulatory bioactives of interest (targeted screening) and determination of their biological effects: Evaluation of the activity of plant bioactives (extracts and purified molecules)

The biodiversity of the natural environment offers very broad perspectives for the study of new molecules of therapeutic interest. Indeed, anti-proliferative properties are regularly described for certain essential oils or plant extracts. In this context, we are seeking to identify new molecules extracted from African food plants. After research into the anti-proliferative activity of total extracts on the proliferation of different cell types (epithelial cells, endothelial cells), a bioguided study is carried out to obtain a purified compound.

Main Publications

Dubois V, Jarde T, Delort L, Billard H, Bernard-Gallon D, Berger E, Geloen A, Vasson MP, Caldefie-Chezet F. Leptin induces a proliferative response in breast cancer cells but not in normal breast cells. Nutr Cancer. 2014 66(4):645-55.

Delort L, Rossary A, Farges MC, Vasson MP, Caldefie-Chézet F. Leptin, adipocytes and breast cancer: focus on inflammation and anti-tumor immunity, Life sciences. 2015, 1;140:37-48.

Ramdani LH, Talhi O, Taibi N, Delort L, Decombat C, Silva A, Bachari K, Vasson MP, Caldefie-Chezet F. Effects of Spiro-bisheterocycles on Proliferation and Apoptosis in Human Breast Cancer Cell Lines. Anticancer Res. 2016 Dec;36(12):6399-6408.

Bougaret L, Delort L, Billard H, Lequeux C, Goncalves-Mendes N, Mojallal A, Damour O, Vasson MP, Caldefie-Chezet F. Supernatants of adipocytes from obese vs normal weight women and breast cancer cells: in vitro impact on angiogenesis. J Cell Physiol. 2017 Jul;232(7):1808-1816.

Bougaret L, Delort L, Billard H, Le Huede C, Boby C, De La Foye A, Rossary A, Mojallal A, Damour O, Vasson MP, Caldefie-Chezet F. Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen. PLoS One. 2018; Feb 1;13(2):e0191571.

Curriculum Vitae

2018 : Authorization to conduct research (HdR), Université Clermont-Auvergne

Since 2008 : Lecturer, UFR Pharmacie, Université Clermont-Auvergne

2007-2008 : Assistant professor, UFR Pharmacie, Université Clermont-Auvergne

2004-2007 : PhD, Centre Jean-Perrin, Clermont-Ferrand