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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Dr François SENEJOUX

SENEJOUX-François

Assistant Professor (Pharm D/Ph D)

Email: francois.senejoux[at]uca.fr
Phone: +33(0)4 73 17 80 33

Research Activities

Purification, isolation and analysis of bioactive natural products

Rational approaches, such as bio-guided fractionation, are currently engaged in order to characterize new constituents capable of modulating immune response. Additionally, original analytical methods are also considered to speed up the search for bioactive constituents from complex biological matrices. For instance, DPPH spiking HPLC assay, a rapid and effective evaluation that directly detects radical scavenging constituents, has been implemented in our team. Of interest, that assay successfully led to the straightforward identification of six bioactive constituents from Detarium microcarpum, an edible African species belonging to Fabaceae family. Furthermore, other innovative HPLC spiking approaches are currently under development. A novel method allowing the immediate detection of nitric oxide scavengers has recently been settled and efficiently applied to the chemical investigation of lemon verbena leaves.

Publications

Meyer JJM, Senejoux F, Heyman HM, Meyer NL, Meyer MA. The occurrence of triterpenoids from Euphorbia gummifera inside the fairy circles of Garub in the southern Namibian. S. Afr. J. Bot. 2015; 98:10-15.

Meda NR, Fraisse D, Gnoula C, Vivier M, Felgines C, Senejoux F. Characterization of antioxidants from Detarium microcarpum Guill. et Perr. leaves using HPLC-DAD coupled with pre-column DPPH assay. Eur Food Res Technol., 2017; 243:1659-1666.

Bonneau N, Baloul L, Bajin Ba Ndob I, Senejoux F, Champy P. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis. Food Chem. 2017; 226:32-40.

Fraisse D, Degerine-Roussel A, Bred A, Ndoye SF, Vivier M, Felgines C, Senejoux F. A novel HPLC method for direct detection of nitric oxide scavengers from complex plant matrices and its application to Aloysia triphylla leaves. Molecules. 2018; 23:1574-1581.

Ndoye SF, Fraisse D, Akendengué B, Gueye RS, Sall C, Gainche M, Seck I, Felgines C, Seck M, Senejoux F. Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L. J. Med. Plants Res. 2019; 13:129-134.

Curriculum Vitae

Since 2013: Assistant Professor in Pharmacognosy and Phytotherapy, UFR Pharmacie, Clermont Auvergne University

2012-2013: Post-Doctoral Training, Department of Plant Sciences, University of Pretoria, South Africa

2011-2012: Lecturer in Pharmacognosy, CNRS UMR 8076, Paris-Sud University

2008-2011: PhD in Phytochemistry, EA 4267 2SBP, Franche-Comté University

2008: Pharm D, Limoges University