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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Luc DEMAISON, PhD

Activities

Email : contact
Tel : +33(0)4 73 60 82 52

Luc Demaison

Food optimization in order to improve cardiac health and human well-being

Dietary nutrients can be beneficial or detrimental for the heart. For instance, excess dietary saturated fats are known to induce obesity, insulin resistance and type-2 diabetes. Long term administration of these fats associated with its resulting hyperglycemia triggers heart failure, diminished autonomy, and finally death. 

My aim is to determine new dietary strategies designed to protect the heart in such circumstances. Several trails exist, but they must be investigated individually or in combination in order to optimize the best dietary regimen for heart failure patients.

Research Activities

The aim of my researches is to improve cardiac function in order to ameliorate human well-being and health. In this context, I evaluate the effects of several nutrients on cardiac health in physiological and pathological conditions.

One of my focuses of interest is to prevent obesity- and type-2 diabetes-induced heart failure by the way of nutrition. It is possible to mimic this pathology in rats and we also study it in obese human being. After feeding the subjects with appropriate nutrients, we evaluate cardiac function in the in vivo situation, but also in the ex vivo situation with rats. We determine the function of cardiac mitochondria in rats and human beings. We also focalize our attention on the reactivity of coronary micro-vessels, since the cardiac mechanical function and mitochondrial energy metabolism depend on oxygen and substrate supply, and thus on the coronary flow.

Another focus of attention shared with one of my co-worker is the fate of patients subjected to cardiac surgery. It is important to optimize the dietary regimen of these patients in order a good post-surgical recovery occurs. Here again, we work on animal and human myocardia, focalizing our attention on cardiac function (mechanical activity and arrhythmias) and mitochondrial energy metabolism.

Publications

  • Leger T, Hininger-Favier I, Capel F, Geloen A, Rigaudière JP, Jouve C, Pitois E, Pineau G, Vaysse C, Chardigny JM, Michalski MC, Malpuech-Brugère C, Demaison L. Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet. Nutr Metab (Lond). 2018 Feb 13;15:15. doi: 10.1186/s12986-018-0252-4.
  • Is there an ‘obesity paradox’ of cardiac survival in heart disease ? A perspective from experimental laboratory studies. 2018. https://prodinra.inra.fr/?locale=fr#!ConsultNotice:421324
  • Patel R, Moffatt JD, Mourmoura E, Demaison L, Seed PT, Poston L, Tribe RM. Effect of reproductive ageing on pregnant mouse uterus and cervix. J Physiol. 2017 Mar 15;595(6):2065-2084. doi: 10.1113/JP273350. Epub 2017 Feb 8. PubMed PMID: 28083928; PubMed Central PMCID: PMC5350451.
  • Mourmoura E, Couturier K, Hininger-Favier I, Malpuech-Brugère C, Azarnoush K, Richardson M, Demaison L. Functional changes of the coronary microvasculature with aging regarding glucose tolerance, energy metabolism, and oxidative stress. Age (Dordr). 2014;36(4):9670. doi: 10.1007/s11357-014-9670-z. Epub 2014 Jul 4. PubMed PMID: 24994535; PubMed Central PMCID: PMC4150905.
  • Mourmoura E, Chaté V, Couturier K, Laillet B, Vial G, Rigaudiere JP, Morio B, Malpuech-Brugère C, Azarnoush K, Demaison L. Body adiposity dictates different mechanisms of increased coronary reactivity related to improved in vivo cardiac function. Cardiovasc Diabetol. 2014 Feb 27;13:54. doi: 10.1186/1475-2840-13-54. PubMed PMID: 24572210; PubMed Central PMCID: PMC3996056.

Curriculum Vitae

- Post-doctoral position at the University of Madison-Wisconsin in a laboratory of cardiology (1986-1987).
- Secretary of the Cardio-Vascular GIS of the University of Burgundy (1995-1998).
- Habilitation of concluding research obtained in October 1995 at the University of Burgundy.
- Fundings from Hoffman-La Roche in order to study the impact of dietary n-3 PUFAs on cardiac function during ischemia/reperfusion.
- Funding from the Burgunda area in order to evaluate cardiac function after physical training in rats fed a n-6 or a n-3 PUFA-rich diet.
- Session organizer at the VIth world congress of Adaptative Medicine in Lyon (September 2000).
- Member of the Specialist Committee of the Burgundy University (1998-2003).
- Member of the animation committee for Agriculture, Development and Prospective of the Burgundy region (200-2003).
- Member of the local Ethic committee for animal experimentation at the University Joseph Fourier of Grenoble (2009-2013).
- Funding from the French National Institute of Agronomical Research in order to evaluate the effects of dietary L-lactate on cardiac function.
- Writer of 57 orginal publications, 1 review paper, 5 book publications , 1 popular piece, and 110 communications at international scientific congresses.
- Tutoring of 3 PhD thesis, 17 Master 2, and 8 Master 1.
- Leader-editor for a special session of the journal Oxidative Medicine and Cellular Longevity.