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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

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Tél: +33(0)4 73 60 82 54


Aging is associated with reductions in muscle quality as well as quantity. There is not only a decrease in muscle cross-sectional area and mass but also infiltration of muscle by fat and connective tissue. There is a decrease in motor units and number and size of fibers, disarrangements of myofilaments, accumulation of oxidative products, reduced satellite cell activation and proliferation, and reduced excitation–contraction coupling. On a metabolic endpoint, an anabolic resistance impairs the metabolic response of protein synthesis to nutrients like amino acids. Thus, understanding these phenomenons is necessary to design nutritional strategies to improve or maintain protein synthesis in skeletal muscle in different physiopathologic situations (aging, metabolic and chronic diseases).

Research Activities

Research focus : Sarcopenia, muscle protein synthesis, signalling pathways, muscle function, mitochondrial energetic metabolism, lipotoxicity, nutrients.

Experimental models : Skeletal muscle cells, rats, mice, genetically modified mice, Humans


  • Salles J., Chanet J., Berry A., Giraudet C., Patrac V., Domingues-Faria C., Rocher C., Guillet C., Denis P., Pouyet C., Bonhomme C., Le Ruyet P., Rolland Y., Boirie Y., Walrand S.  (2017) Fast digestive, leucine-rich, soluble milk proteins improve muscle protein anabolism and mitochondrial funct
  • Chanet A., Salles J., Guillet C., Giraudet C., Berry A., Patrac V, Domingues-Faria C., Tagliaferri C., Bouton K., Bertrand-Michel J., Van Dijk M., Jourdan M., Luiking Y., Verlaan S., Pouyet C., Denis P., Boirie Y., Walrand S. (2017) Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient.
  • Tardif N.*, Salles J.*, Guillet C., Tordjman J., Reggio S., Landrier JF., Giraudet G., Patrac V., Bertrand-Michel J., Migne C., Collin ML, Chardigny JM, Boirie Y., Walrand S. (2014) Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation. Aging Cell 13(6):1001-11.
  • Salles J., Chanet A., Giraudet C., Patrac V., Pierre P., Jourdan M., Luiking Y.C., Verlaan S., Migné C., Boirie Y., Walrand S. (2013) 1,25(OH)2 -vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res. 57, 2137–2146
  • Salles J., Tardif N., Landrier JF., Mothe-Satney I., Guillet C., Boue-Vaysse C., Combaret L., Giraudet C., Patrac V., Bertrand-Michel J., Denis P., Chardigny JM., Boirie Y., Walrand S.(2012) TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice. J. Nutr. Biochem., 23(12), 1685-1693.
  • Tardif N., Salles J., Landrier J-F., Mothe-Satney I., Guillet C., Boue-Vaysse C., Combaret L., Giraudet C., Patrac V., Bertrand-Michel J., Migné C., Chardigny J-M., Boirie Y., Walrand S. (2011) Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats. Clinical Nutrition, 30(6), 799-806.