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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Frédéric CAPEL, PhD

Activities

Email : contact
Tel : +33(0)4 73 17 82 67

I've obtained a PhD (2004) in Life Sciences on the relationship between the loss of skeletal muscle with aging and the alterations in mitochondrial functions (energy & reactive oxygen species productions). Between 2005 and 2010, I had the opportunity to be introduced to functional genomic to study the regulation of gene expression in insulin-sensitive tissues depending on population (obese, elderly people) nutritional status. In 2010, I joined the Human Nutrition Unit of the INRA as a research scientist. I work on nutritional strategies based on dietary fats to prevent metabolic disorders linked to excess body fat. It is now well established that the quality of dietary fatty acids is crucial in the prevention of many pathologies. Some classes of fatty acids could help at preventing the accumulation of deleterious lipid metabolites and some metabolic disorders or inflammation. I used both in vitro (cellular approaches) and in vivo/physiological (animal models, human interventions) to understand and modify the relationship between lipid metabolism, adipose tissue and skeletal muscle physiology.

Research Activities

Ongoing projects are related to the effect of omega 3 PUFAs in the prevention of obesity-associated metabolic disorders:

Prevention of the accumulation of toxic lipid metabolites in skeletal muscle (phospholipids, diacylglycerols, ceramides) and the progression of inflammation

Impact on the development of adipose tissue and modulation of its metabolism

In vitro analysis of the physiologic/metabolic relationship between adipose and muscle cells

Other projects concerned the identification of lipid markers (fatty acids, phospholipids) of metabolic disorders (in relation with clinicians) or specific dietary intakes.

Publications

Capel, F., C. Acquaviva, et al. (2015). "DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation." J Nutr Biochem 26(9): 949-959.
Capel, F., N. Cheraiti, et al. (2016). "Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes." Biochim Biophys Acta 1861(12 Pt A): 2000-2010.
Capel, F., E. Klimcakova, et al. (2009). "Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization." Diabetes 58(7): 1558-1567.
Ennequin, G., F. Capel, F et al. (2017). "Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice." Sci Rep 7(1): 1742.
Pinel, A., E. Pitois, et al. (2016). "EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet." J Lipid Res.
Pinel, A., J. P. Rigaudiere, et al. (2015). "N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells." Biochim Biophys Acta.

Curriculum Vitae

Since 2010: INRA, Unité de Nutrition Humaine, Clermont-Ferrand-Theix, France

2008-10: Institut de Recherches Servier, Croissy-sur-Seine, France.

2005-08: INSERM U858 - Unité de Recherches sur les Obésités, Toulouse, France

2001-04: PhD, INRA, Unité de Nutrition et Métabolisme Protéique, Clermont-Ferrand-Theix, France

Research programs funded by IEED GENESYS P.I.V.E.R.T (3 programs 2013-2017), Avril, European FP7 program (NuAge -2016), ANSSD program of INRA (2011-2012) région Auvergne-FEDER (Prix nouveau chercheur 2015-2017 Région Auvergne)