Dr Céline JOUSSE

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Tel : +33(0)4 73 62 49 39

Metabolic diseases have multiple origins ranging from genetic and environmental factors. A key feature characteristic of these diseases is that transient environmental influences such as a nutritional stress during perinatal life may induce deleterious heritable health effects that may last for the entire life of individual. This "nutritional programming" has also been reported in animals but the molecular mechanisms involved are not understood. Since the consequences of the events occurring in early life are maintained throughout life, epigenetic modifications are likely to play an important role in this process. Among these modifications, DNA methylation is the best-studied and has been shown to be affected by various environmental stimuli.

In that context, our aim is to identify (1) epigenetic biomarkers that may be used to identify at risk population in human (2) signaling pathways affected by epigenetic regulation; these pathways could be considered as potential drug target and (3) the molecular mechanisms involved in these regulations.

 Activité de recherche       Publications       Parcours et Éléments de CV

[1]       C. Chaveroux, V. Carraro, L. Canaple, J. Averous, A.-C. Maurin, C. Jousse, Y. Muranishi, L. Parry, F. Mesclon, E. Gatti, J. Mallet, P. Ravassard, P. Pierre, P. Fafournoux, and A. Bruhat, “In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders.,” Science Signaling, vol. 8, no. 374, pp. rs5–rs5, Apr. 2015.

[2]       J. Averous, S. Lambert-Langlais, V. Carraro, O. Gourbeyre, L. Parry, W. B’chir, Y. Muranishi, C. Jousse, A. Bruhat, A.-C. Maurin, C. G. Proud, and P. Fafournoux, “Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.,” Cellular Signalling, vol. 26, no. 9, pp. 1918–1927, Sep. 2014.

[3]       A.-C. Maurin, A. Benani, A. Lorsignol, X. Brenachot, L. Parry, V. Carraro, C. Guissard, J. Averous, C. Jousse, A. Bruhat, C. Chaveroux, W. B’chir, Y. Muranishi, D. Ron, L. Pénicaud, and P. Fafournoux, “Hypothalamic eIF2α signaling regulates food intake.,” CellReports, vol. 6, no. 3, pp. 438–444, Feb. 2014.

[4]       C. Jousse, Y. Muranishi, L. Parry, C. Montaurier, P. Even, J.-M. Launay, V. Carraro, A.-C. Maurin, J. Averous, C. Chaveroux, A. Bruhat, J. Mallet, B. Morio, and P. Fafournoux, “Perinatal protein malnutrition affects mitochondrial function in adult and results in a resistance to high fat diet-induced obesity.,” PLoS ONE, vol. 9, no. 8, p. e104896, 2014.

[5]       C. Jousse, L. Parry, S. Lambert-Langlais, A.-C. Maurin, J. Averous, A. Bruhat, V. Carraro, J. Tost, P. Letteron, P. Chen, R. Jockers, J.-M. Launay, J. Mallet, and P. Fafournoux, “Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome.,” FASEB J., vol. 25, no. 9, pp. 3271–3278, Sep. 2011.