Know more

About cookies

What is a "cookie"?

A "cookie" is a piece of information, usually small and identified by a name, which may be sent to your browser by a website you are visiting. Your web browser will store it for a period of time, and send it back to the web server each time you log on again.

Different types of cookies are placed on the sites:

  • Cookies strictly necessary for the proper functioning of the site
  • Cookies deposited by third party sites to improve the interactivity of the site, to collect statistics

Learn more about cookies and how they work

The different types of cookies used on this site

Cookies strictly necessary for the site to function

These cookies allow the main services of the site to function optimally. You can technically block them using your browser settings but your experience on the site may be degraded.

Furthermore, you have the possibility of opposing the use of audience measurement tracers strictly necessary for the functioning and current administration of the website in the cookie management window accessible via the link located in the footer of the site.

Technical cookies

Name of the cookie


Shelf life

CAS and PHP session cookies

Login credentials, session security



Saving your cookie consent choices

12 months

Audience measurement cookies (AT Internet)

Name of the cookie


Shelf life


Trace the visitor's route in order to establish visit statistics.

13 months


Store the anonymous ID of the visitor who starts the first time he visits the site

13 months


Identify the numbers (unique identifiers of a site) seen by the visitor and store the visitor's identifiers.

13 months

About the AT Internet audience measurement tool :

AT Internet's audience measurement tool Analytics is deployed on this site in order to obtain information on visitors' navigation and to improve its use.

The French data protection authority (CNIL) has granted an exemption to AT Internet's Web Analytics cookie. This tool is thus exempt from the collection of the Internet user's consent with regard to the deposit of analytics cookies. However, you can refuse the deposit of these cookies via the cookie management panel.

Good to know:

  • The data collected are not cross-checked with other processing operations
  • The deposited cookie is only used to produce anonymous statistics
  • The cookie does not allow the user's navigation on other sites to be tracked.

Third party cookies to improve the interactivity of the site

This site relies on certain services provided by third parties which allow :

  • to offer interactive content;
  • improve usability and facilitate the sharing of content on social networks;
  • view videos and animated presentations directly on our website;
  • protect form entries from robots;
  • monitor the performance of the site.

These third parties will collect and use your browsing data for their own purposes.

How to accept or reject cookies

When you start browsing an eZpublish site, the appearance of the "cookies" banner allows you to accept or refuse all the cookies we use. This banner will be displayed as long as you have not made a choice, even if you are browsing on another page of the site.

You can change your choices at any time by clicking on the "Cookie Management" link.

You can manage these cookies in your browser. Here are the procedures to follow: Firefox; Chrome; Explorer; Safari; Opera

For more information about the cookies we use, you can contact INRAE's Data Protection Officer by email at or by post at :


24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal Clermont Auvergne University


Joint Research Unit 1095 Genetics, Diversity and Ecophysiology of Cereals

Axis 3 - Exploring the UPR pathway in relation to protein maturation

The various stages of protein maturation and folding involve glycosylations and the formation of disulfide bridges that begin in the endoplasmic reticulum (ER). These processes can be impacted by environmental conditions, such as high temperatures, and can alter protein maturation, leading to a modification of the gluten network. When the ER is stressed by too many malformed proteins, a cellular regulation pathway, called the Unfolded Protein Response (UPR), is activated. The objective is to study the involvement of this pathway in the maturation of storage proteins. To do this, we are evaluating the level of expression of the UPR pathway genes in lines that are contrasted for the size of the polymers that will be identified (GlutNSafe FSOV project). Eventually, these genes could serve as biomarkers for phenotyping the effect of high temperatures on the maturation of storage proteins.


In eukaryotes, it is estimated that about 1/3 of the total protein corresponds to secreted or membrane proteins. The synthesis of this class of proteins begins in the cytoplasm and continues in the endoplasmic reticulum (ER) where these proteins undergo correct maturation and folding steps. Abiotic stresses, such as heat stress, lead to an accumulation of unfolded or misfolded proteins leading to ER stress. In response to this stress, the cell reacts, on the one hand by increasing the production of chaperone proteins and on the other hand by limiting the flow of proteins arriving in the ER via a proteolysis phenomenon called ER-Associated-Degradation (ERAD).